is an oral drug used for the treatment and
prevention of severe acne. Acne is caused
by inflammation of the skin. It primarily
affects teenagers, but it also affects adults.
Severe acne causes permanent scarring of the
skin. The inflammation is caused in part by
an increased secretion of sebum (oily substance)
from glands in the skin (sebaceous glands).
The sebum provokes inflammation, and the inflammation
resolves (heals) with the formation of a scar
(keratinization). The exact mechanism of action
of Isotretinoin is not known; however, it
may reduce acne by reducing the secretion
of sebum. If less sebum is secreted it is
likely that there will be less inflammation
and keratinization. The Food and Drug Administration
approved Isotretinoin in 1982.
Isotretinoin is used to treat severe acne